Principal Investigators

    Mathias Hallberg


    Uppsala University

    Contact information of lead PI



    Title of project or programme

    Framtagning och karaktärisering av en ny typ av kognitionsförstärkare. 69/5000 Did you mean: Framtagning och karaktärisering av en ny typ av kognition förstärkare Development and characterization of a new type of cognition enhancer

    Source of funding information

    The Swedish Brain Foundation

    Total sum awarded (Euro)

    € 54,407

    Start date of award


    Total duration of award in years



    Research Abstract

    Alzheimer’s (AD) disease is a neurodegenerative disease characterized by general cognitive impairment and difficulties with memory consolidation and retrieval. There are no effective drug treatments available and none of the pharmaceuticals used in clinic (cholinesterase inhibitors and
    N-methyl-D-aspartate receptor antagonists) address the underlying progressive loss of synaptic connections and neurons. We believe that substances that improve memory dysfunctions by augmenting synaptic connectivity via the formation of new functional synapses might have a
    potential to serve not only as important research tools for animal studies but more importantly, after structural optimization, also as future drugs for the treatment of Alzheimer’s disease.
    However, to properly design such substances that survive the cascade of metabolizing enzymes and that are able to cross various barriers e.g. blood-brain barrier (BBB) and effectively reach target neurons in the brain, is a tremendous challenge.

    Further information available at:

Types: Investments < €500k
Member States: Sweden
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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