Principal Investigators

    Dr. M.W. Vernooij



    Contact information of lead PI



    Title of project or programme

    Functional brain connectivity: a new imaging marker for preclinical dementia?

    Source of funding information


    Total sum awarded (Euro)

    € 160,000

    Start date of award


    Total duration of award in years



    Research Abstract

    To fully assess the potential of assessment of resting-state network activity as a very early, preclinical marker of Alzheimer’s disease or other dementing disorders, a large-scale prospective population study is required in which participants undergo detailed examinations at baseline, including rs-fMRI, and are subsequently followed for the occurrence of dementia. The present project will perform rs-fMRI in 2,000 middle aged and elderly participants from the longitudinal population-based Rotterdam Study. Measures of functional brain connectitivity will be related to structural brain imaging markers and to known genetic and non-genetic risk factors for dementia. Furthermore, the association between functional connectivity and cognitive function and the risk of developing dementia will be assessed. The ultimate aim of this project is to evaluate the value of functional brain connectivity as a new imaging marker of preclinical dementia

    Further information available at:

Types: Investments < €500k
Member States: Netherlands
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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