Principal Investigators


SINGLETON, ANDREW

Institution


National Institute on Aging

Contact information of lead PI


Country


USA

Title of project or programme


Genetic Analysis Of Alzheimer s Disease

Source of funding information


NIH (NIA)

Total sum awarded (Euro)


€ 608,180.73

Start date of award


Total duration of award in years


15

The project/programme is most relevant to:


Alzheimer's disease & other dementias

Keywords


Acquired Cognitive Impairment... Aging... Alzheimer's Disease... Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)... Brain Disorders... Dementia... Genetics... Human Genome... Neurodegenerative... Prevention

Research Abstract


We continue to be a contributor to the reanalysis of large tracts of genome wide association data and much of this work, which identifies several new loci, and a converging molecular pathway, has been published. Most recently we continue our efforts using second generation sequencing (which previously lead to the identification of TREM2 and TREML2, and PLD3 variants as a risk factor for Alzheimer’s disease). We have followed up on that work with continued characterization of known AD loci in relatively small series of patients. We are contributing members to consortia that continue to investigate various aspects of AD genetics.

Lay Summary


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