Name of Fellow

    Christopher Medway



    Alzheimer's Research UK

    Contact information of fellow


    United Kingdom

    Title of project/programme

    High-throughput genotyping of rare variants identified through next-generation sequencing of Alzheimer's disease candidate genes

    Source of funding information

    Alzheimer's Research UK

    Total sum awarded (Euro)

    € 137,446

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    Genetics | Next Generation Sequencing

    Research Abstract

    Since 2006 the Nottingham Alzheimer’s Research UK (ARUK) centre has developed a strong working relationship with the Mayo Clinic, Florida headed by Prof Steve Younkin (SY). The support of Alzheimer’s Research UK has been instrumental in this partnership; funding Kevin Morgan (KM) to visit the Mayo Clinic and Olivia Belbin (OB) to undertake a two year post-doctoral position.

    The strength of this collaboration is a ‘bank’ of over 10,000 patient samples (one of the largest in the world) – an ideal resource for large genetic association studies; as exemplified by our joint publications on the ‘top’ 25 AD genes to date. With OB having completed her position in 2010, there is an opportunity for myself (CM) to continue this relationship.

    We plan to utilise the shared resource to perform high-throughput replication studies of common and rare variants currently being discovered through our targeted resequencing of Alzheimer’s disease candidate genes. As 6-months funding has already been committed by SY at the Mayo Clinic, we are applying for 2.5 years further funding; 6-months matched funding for one year at the Mayo Clinic, which will be preceded by 6-months preparation in the UK and proceeded by 1.5 years back in the KM lab.

Types: Fellowships
Member States: United Kingdom
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

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