Christopher Medway
Alzheimer's Research UK
United Kingdom
High-throughput genotyping of rare variants identified through next-generation sequencing of Alzheimer's disease candidate genes
Alzheimer's Research UK
137,446
01/01/13
3.3
Alzheimer's disease & other dementias
Genetics | Next Generation Sequencing
Since 2006 the Nottingham Alzheimer’s Research UK (ARUK) centre has developed a strong working relationship with the Mayo Clinic, Florida headed by Prof Steve Younkin (SY). The support of Alzheimers Research UK has been instrumental in this partnership; funding Kevin Morgan (KM) to visit the Mayo Clinic and Olivia Belbin (OB) to undertake a two year post-doctoral position.
The strength of this collaboration is a ‘bank’ of over 10,000 patient samples (one of the largest in the world) an ideal resource for large genetic association studies; as exemplified by our joint publications on the top 25 AD genes to date. With OB having completed her position in 2010, there is an opportunity for myself (CM) to continue this relationship.
We plan to utilise the shared resource to perform high-throughput replication studies of common and rare variants currently being discovered through our targeted resequencing of Alzheimer’s disease candidate genes. As 6-months funding has already been committed by SY at the Mayo Clinic, we are applying for 2.5 years further funding; 6-months matched funding for one year at the Mayo Clinic, which will be preceded by 6-months preparation in the UK and proceeded by 1.5 years back in the KM lab.