Name of Fellow


Dr Sarah Rea

Institution


Funder


NHMRC

Contact information of fellow


Country


Australia

Title of project/programme


How do mutations in autophagy receptors cause FTD and ALS?

Source of funding information


NHMRC

Total sum awarded (Euro)


€ 384,623

Start date of award


01/01/16

Total duration of award in years


4.0

The project/programme is most relevant to:


Alzheimer's disease & other dementias

Keywords


proteomics | autophagy | cell signalling | protein interactions | dementia

Research Abstract


As cells age the “garbage disposal” process within cells slows down, becoming less functional. In inherited forms of dementia the genes involved often code for damaged proteins that “clog up” the disposal system or directly affect the “garbage men”. These defective garbage men genes include SQSTM1/p62, OPTN, VCP and UBQLN2. We will determine how these defective genes lead to build up of garbage in neuronal cells and how leads to disease.

Export as PDF