Name of Fellow

    Dr Vasiliki Orgeta



    Alzheimer's Society

    Contact information of fellow


    United Kingdom

    Title of project/programme

    IDEA Intervention to prevent Depressive symptoms and promote well-being in EArly stage dementia development and feasibility

    Source of funding information

    Alzheimer's Society

    Total sum awarded (Euro)

    € 473,580

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    Research Abstract

    Depression in dementia is a highly common syndrome producing substantial decrements in well-being. People with dementia and depression experience more functional and behavioural problems, and are at high risk of entering care. Anti-depressants are ineffective in treating or reducing depressive symptoms. Given therefore the serious burden of depression and limited treatment options, preventing, or at least delaying the onset of depression in people with dementia is a major clinical priority.

    Existing research in psychological interventions in dementia suggests that these can reduce depressive symptoms but definitive evidence is lacking. The primary aim of the proposed research is to develop a coping intervention to prevent depressive symptoms for people with early-stage dementia. The development of the intervention will be guided by Medical Research Council (MRC) guidelines, preventive interventions for depression in late life and in-depth consultations with key-stakeholders. The secondary objective is to test the feasibility and acceptability of the intervention.

    A total of 60 people with dementia will be recruited, with minimum size needed to estimate acceptability being 56 (expected value 75%, 95% Confidence Intervals (CIs) = 59-87%). Participants will have a diagnosis of early-stage dementia, will be living in the community and have a carer who can participate in the intervention. The feasibility study will estimate parameters for a main definitive trial such as number of eligible participants, percentage finding the intervention acceptable, follow-up rates, and number of sessions attended. Additional data collected will be suitability of outcome measures and piloting procedures and parameters for a future trial.

Types: Fellowships
Member States: United Kingdom
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

Export as PDF