Name of Fellow

    Eline Wauters



    Contact information of fellow



    Title of project/programme

    Identification of genetic modifiers of onset age in frontotemporal lobar degeneration: a family-based integrative approach

    Source of funding information

    Total sum awarded (Euro)

    € 146,886

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    family based integrative approach | frontotemporal lobar degeneration of FTLD | identification of genetic modifier. QTL

    Research Abstract

    The aim of this PhD project is to identify genetic modifiers underlying the wide variation in onset age in frontotemporal lobar degeneration or FTLD. A quantitative trait locus (QTL) for onset age was identified in an extended Flanders-Belgian FTLD founder pedigree (DR8 family) segregating a causal mutation in the granulin gene. To identify the functional variation underlying the QTL, we apply a multi-omics approach combining whole genome sequencing with brain whole transcriptome and serum whole proteome analysis of members of the DR8 family

Types: Fellowships
Member States: Belgium
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

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