Principal Investigators

    Prof. dr. Johannes de Boer


    VU University of Amsterdam, Dept. of Physics and Astronomy

    Contact information of lead PI



    Title of project or programme

    Imaging the Retina for Early Alzheimer Diagnosis (I-READ)

    Source of funding information


    Total sum awarded (Euro)

    € 749,267

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    Research Abstract

    Pre-clinical studies have demonstrated that amyloid beta (A?) plaques, a well-known hallmark of AD, can be optically detected in the retina of live mouse models and in post-mortem human eyes of AD patients using curcumin as fluorescent dye. A major challenge in translating these preclinical results to use in patients is the presence of strong autofluorescence in the retina which leads to a poor signal-to-background ratio. We propose to develop a multi-wavelength, depth-sensitive confocal fluorescence scanning laser ophthalmoscope for efficient, non-invasive imaging of A? plaques in the human retina. The use of dual wavelength excitation and depth-sensitive detection will allow discrimination of curcumin labeled A? and autofluorescence background. The method will be evaluated in a proof of principle study in 20 subjects at the Alzheimer Center of the VU University medical center.

    Lay Summary

    Further information available at:

Types: Investments > €500k
Member States: Netherlands
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

Export as PDF