Principal Investigators

    Shohreh Issazadeh-Navikas


    Københavns Universitet

    Contact information of lead PI



    Title of project or programme

    Immune genes impact on development of a-synucleinopathy

    Source of funding information


    Total sum awarded (Euro)

    € 211,882

    Start date of award


    Total duration of award in years



    Research Abstract

    Despite recent progress in understanding the pathogenesis of Parkinson’s disease and Lewy Body dementia no curative treatments are available. Dysfunctional autophagy has been associated with these diseases causing accumulation of aggregation prone proteins, a common feature of many age-related neurodegenerative diseases. We have found if interferon (IFN)-ß and/or its receptor IFN-A/B receptor is knockout (Ifnb–/–, Ifnar–/– respectively) mice display spontaneous neurodegeneration, motor-coordination and cognitive deficits resembling Parkinson’s disease dementia and Dementia with Lewy Bodies, and our recent data strongly suggest that this is caused by dysfunctional autophagy. The research aims for the PhD program are to uncover underlining molecular mechanisms of how IFN-ß signaling regulates a) autophagy with specific emphasis on the PI3K/Akt1/FoxO1 pathway, b) trafficking of autophagosomes along the microtubule network and c) IFN-ߒs therapeutic potential via autophagy regulation.

    Further information available at:

Types: Investments < €500k
Member States: Denmark
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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