Principal Investigators

    Park, David SGibbings, Derrick J; Hayley, Shawn P; Philpott, Dana J; Rioux, John D; Schlossmacher, Michael G; Schurr, Erwin A


    University of Ottawa

    Contact information of lead PI



    Title of project or programme

    Insights into Parkinson's disease, Crohn's disease, and leprosy: a common role for LRRK2

    Source of funding information


    Total sum awarded (Euro)

    € 1,588,275

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Parkinson's disease & PD-related disorders


    Research Abstract

    The immune system has increasingly been shown to play a role in various disease states, though the manner by which the immune system responds is complex and not fully understood. Recent evidence has identified a potential common immune system response that may underlie three different chronic diseases: Parkinson’s disease, Crohn’s disease, and leprosy. LRRK2 is a gene that has been associated with an increased susceptibility for these diseases, and is thought to play a role in regulating immune system function. The present research is designed to develop a comprehensive understanding of the role of LRRK2 in immune system modulation, and how dysfunction of this pathway may lead to the development of Parkinson’s disease, Crohn’s disease, or leprosy. To achieve this we have assembled a multidisciplinary team with expertise in LRRK2 biology, genetics, and the immune system. Together, these three disorders represent an incredible burden on health care costs and human suffering worldwide. The identification of commonalities related to immune dysregulation could lead to unique therapeutic strategies, and has the potential to transform clinical outcomes of patients suffering from these conditions.

    Lay Summary

    Further information available at:

Types: Investments > €500k
Member States: Canada
Diseases: Parkinson's disease & PD-related disorders
Years: 2016
Database Categories: N/A
Database Tags: N/A

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