Name of Fellow

    Pablo Garcia Reitboeck



    Alzheimer's Research UK

    Contact information of fellow


    United Kingdom

    Title of project/programme

    Investigating the role of the microglial receptor TREM2 in Alzheimer's disease

    Source of funding information

    Alzheimer's Research UK

    Total sum awarded (Euro)

    € 223,783

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    Immunity and Inflammation | Microglia

    Research Abstract

    Recent genetic studies point to a prominent role of the immune system in Alzheimer’s disease (AD). Variations in the immune receptor gene TREM2 (triggering receptor expressed on myeloid cells 2), which in the nervous system is active in microglia, the resident brain immune cells, were recently identified as a risk factor for developing AD.

    We plan to study the function of TREM2 in microglia and in particular, whether microglia with faulty TREM2 respond abnormally to amyloid ?, the sticky protein that accumulates widely in AD brains and is thought to have a major role in the disease process. We plan to identify the functional changes in microglia with TREM2 defects and compare them with unaffected microglia.

    As a model we will use human stem cell-derived microglia, by reprogramming skin cell derived induced pluripotent stem cells (iPSCs) of patients with Nasu-Hakola disease, an inherited early-onset dementia caused by two faulty copies of the TREM2 gene, as well as unaffected relatives who carry one copy of the faulty TREM2 gene.

    The ultimate aim of this research is to gain insight into the role of TREM2 and microglia in the development of AD in order to identify new therapeutic targets.

Types: Fellowships
Member States: United Kingdom
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

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