Dr Sivaraman Purushothuman
Lewy bodies in patients with dementia Determining common and unique mechanisms in relation to Alzheimers disease
Alzheimer's disease & other dementias
dementia with lewy bodies | alzheimer disease | pathogenic mechanisms | ageing | dementia
Alzheimers disease is the most common type of dementia but often has multiple mixed pathologies. For example, Alzheimer post mortem brains may have abnormal accumulation of Lewy bodies in certain parts of the brains, and could be diagnosed as Lewy body disease. This may represent a skewed representation of some dementia subtypes. This project will identify the biological determinants of dementia patients with Lewy body disease for better understanding and future therapeutic targeting.