Dr. A.W. Lemstra
VU medisch centrum
Netherlands
Longitudinal DLB Cohort
Alzheimer Nederland
155,000
01/09/2015
4
Dementia with Lewy Bodies (DLB) is a devastating neurodegenerative disease that. It is the most common form of dementia next to Alzheimers disease (around 30.000-50.000 patients in the Netherlands). The overall aim of this project is to investigate the clinical relevance of AD-pathology in early stages of DLB and to understand the biological factors that contribute to this effect, in order to improve care and offer personalized treatment strategies for DLB-patients. AD-pathology is detected by CSF-biomarkers.
The following objectives are specified:
1) To compare cross-sectional data in DLB-AD+ and DLB-AD- clinical symptoms, neuropsychological profile, MRI-characteristics (atrophy, vascular lesions) and EEG
2) To compare disease progression and survival (nursing home admission and death) in DLB-AD+ and DLB-AD- patients. Longitudinal clinical data, neuropsychological data as well as biomarkers will be analysed
3) To compare genetic profiles of DLB-AD+ and DLB-AD- by analysis of NeuroX analyses of DNA of DLB-patients
4) To compare levels of CSF amyloid-beta species (Abeta38/40/42) in DLB-AD+, DLB-AD and AD
5) To compare histopathological features in a subset of autopsy-proven DLB-patients