Principal Investigators

    Kalra, Sanjay


    University of Alberta

    Contact information of lead PI



    Title of project or programme

    Magnetic resonance imaging biomarkers in ALS

    Source of funding information


    Total sum awarded (Euro)

    € 547,136

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Motor neurone diseases


    Research Abstract

    Amyotrophic lateral sclerosis (ALS) is a disabling, rapidly progressive, and fatal neurodegenerative disorder. There is no treatment that significantly slows progression. Increasing age is an important risk factor for developing ALS; thus, the societal impact of this devastating disease will become more profound as the population ages. A significant hurdle to finding effective treatment has been an inability to accurately measure brain degeneration in humans. Advanced magnetic resonance imaging (MRI) techniques hold promise in this respect, and may assist in aiding diagnosis, prognostication, and the efficient testing of new drugs. In this multicentre study, different MRI features of brain degeneration will be measured in a large sample of patients with ALS. The ability of these MRI features to track disease progression will be tested.

    Lay Summary

    Further information available at:

Types: Investments > €500k
Member States: Canada
Diseases: Motor neurone diseases
Years: 2016
Database Categories: N/A
Database Tags: N/A

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