Principal Investigators

    Angela Cenci Nilsson


    Lund University

    Contact information of lead PI



    Title of project or programme

    Maladaptive plasticity in the basal ganglia: focus on Parkinson´s disease and its treatment

    Source of funding information

    Swedish Research Council

    Total sum awarded (Euro)

    € 734,494

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Parkinson's disease & PD-related disorders


    Research Abstract

    Dopamine (DA) modulates neuroplasticity in the basal ganglia, and the loss of DA in Parkinson´s disease (PD) causes dysfunctional adaptations in dopaminoceptive cells. DA replacement with either L-DOPA or cell transplants causes additional changes that underlie the development of dyskinesia. SPECIFIC AIMS i-iv will uncover patterns of dendritic and synaptic alterations that are induced in specific types of striatal neurons by PD-like pathology, L-DOPA treatment, or transplantation of ventral mesencephalic neurons (rodent models, slice electrophysiology, two-photon microscopy, morphology, molecular biology). We shall also examine the therapeutic potential of non-dopaminergic compounds that target synaptic or perisynaptic proteins (behavioural pharmacology, neurohistology, and functional analyses). SPECIFIC AIMS v-vi will address the relationship between abnormal neurovascular coupling and angiogenesis in the basal ganglia upon chronic L-DOPA treatment (autoradiography and PET studies of regional cerebral blood flow and metabolism in rat models of PD). Moreover, we shall define wet biomarkers of angiogenic and inflammatory activation in human PD patients, addressing their relationship with dyskinesia and other symptoms, as well as their possible response to continuous L-DOPA delivery. SIGNIFICANCE: Our results will uncover basic mechanisms of maladaptive plasticity in neurodegenerative diseases of basal ganglia origin and will develop novel treatments and biomarkers for PD.

    Lay Summary

    Further information available at:

Types: Investments > €500k
Member States: Sweden
Diseases: Parkinson's disease & PD-related disorders
Years: 2016
Database Categories: N/A
Database Tags: N/A

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