Name of Fellow

    Josephine Barnes



    Alzheimer's Research UK

    Contact information of fellow


    United Kingdom

    Title of project/programme

    Measuring, Tracking and Disentangling the Impact of White Matter Disease in AD and Mixed Disease: A Longitudinal MRI and CSF Study

    Source of funding information

    Alzheimer's Research UK

    Total sum awarded (Euro)

    € 327,857

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    Multimodal Biomarkers

    Research Abstract

    People with Alzheimer’s disease (AD) often have evidence of vascular damage in their brains as well as Alzheimer’s pathology (amyloid and tau). Understanding the relative contributions of each pathology to disease progression is extremely important for numerous reasons. Trials of possible AD treatments are moving to earlier disease stages in order to prevent and halt, rather than treat disease, and even at these earlier stages vascular damage has an impact on progression. Those with more vascular damage may also respond differently to treatments and may have differing prognoses compared with those without such damage. This project will develop techniques to measure and assess the correlates of vascular damage using magnetic resonance imaging. We will make these techniques freely available for other centres to use. We will disentangle the relationships between AD pathology and vascular damage in terms of how each acts to increase disease progression and when each has the greatest influence. In this project we aim to gain understanding of these relationships which will provide better information for those designing clinical trials, for clinicians and also, most importantly, for patients.

Types: Fellowships
Member States: United Kingdom
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

Export as PDF