Name of Fellow


Josephine Barnes

Institution


Funder


Alzheimer's Research UK

Contact information of fellow


Country


United Kingdom

Title of project/programme


Measuring, Tracking and Disentangling the Impact of White Matter Disease in AD and Mixed Disease: A Longitudinal MRI and CSF Study

Source of funding information


Alzheimer's Research UK

Total sum awarded (Euro)


€ 327,857

Start date of award


01/08/13

Total duration of award in years


3.5

The project/programme is most relevant to:


Alzheimer's disease & other dementias

Keywords


Multimodal Biomarkers

Research Abstract


People with Alzheimer’s disease (AD) often have evidence of vascular damage in their brains as well as Alzheimer’s pathology (amyloid and tau). Understanding the relative contributions of each pathology to disease progression is extremely important for numerous reasons. Trials of possible AD treatments are moving to earlier disease stages in order to prevent and halt, rather than treat disease, and even at these earlier stages vascular damage has an impact on progression. Those with more vascular damage may also respond differently to treatments and may have differing prognoses compared with those without such damage. This project will develop techniques to measure and assess the correlates of vascular damage using magnetic resonance imaging. We will make these techniques freely available for other centres to use. We will disentangle the relationships between AD pathology and vascular damage in terms of how each acts to increase disease progression and when each has the greatest influence. In this project we aim to gain understanding of these relationships which will provide better information for those designing clinical trials, for clinicians and also, most importantly, for patients.

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