Principal Investigators

    Stanimirovic, Danica


    University of Ottawa

    Contact information of lead PI



    Title of project or programme

    Mechanisms of amyloid-beta clearance in models of vascular cognitive impairment and mixed dementia

    Source of funding information


    Total sum awarded (Euro)

    € 192,221

    Start date of award


    Total duration of award in years



    Research Abstract

    In the aging brain two major events contribute to loss of memory and dementia: disease of brain vessels and accumulation of a protein, amyloid, that causes brain inflammation. This project will study how these processes work together to cause cognitive decline. The project will also test effects of new molecules designed to speed up the elimination of toxic amyloid from the brain. This will be evaluated in animal models using strong expertise of German and Canadian researchers and their advanced imaging techniques. Should the treatments prove effective, the project will proceed to more rigorous evaluation of these molecules for their application in human patients.

    Further information available at:

Types: Investments < €500k
Member States: Canada
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

Export as PDF