Mr Matthew Fogarty
Mechanisms of cortical and respiratory degenerations in Amyotrophic Lateral Sclerosis
Motor neurone diseases
amyotrophic lateral sclerosis | pathogenic mechanisms | patch clamp | motor cortex | molecular basis of disease
This study will be the first to chronicle how and when motor neurons (MNs) in the brain and spinal cord degenerate before, during and after ALS symptoms in 2 different mouse models. The MNs studied control breathing muscles and are a key disease progression and mortality indicator in patients. I expect drastic shape and electrical abnormalities, providing information useful to clinicians about how and when brain and spinal cord MNs degenerate, uncovering new therapeutic targets and time-points.