Principal Investigators

    Park, David S


    University of Ottawa

    Contact information of lead PI



    Title of project or programme

    Mechanisms of DJ-1 in an aging model of PD

    Source of funding information


    Total sum awarded (Euro)

    € 601,738

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Parkinson's disease & PD-related disorders


    Research Abstract

    Aging is a critical factor in the incidence of Parkinsons disease (PD). However, the initial causes of the disease are mostly unknown. One impediment to understanding the disease has been the lack of animal models of PD. Here we propose to generate one such chronic degenerative model based upon the loss of a gene, DJ-1, known to cause rare forms of PD. We propose to examine how loss of this gene sensitizes animals to environmental toxins known to cause the same loss of neurons as in PD. We will also explore how DJ-1 loss itself may cause spontaneous death of these neurons in the live animal. These studies will provide important new insights into how PD progresses and provide new potential avenues of therapeutics.

    Lay Summary

    Further information available at:

Types: Investments > €500k
Member States: Canada
Diseases: Parkinson's disease & PD-related disorders
Years: 2016
Database Categories: N/A
Database Tags: N/A

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