Principal Investigators

    Professor Karen Horsburgh


    University of Edinburgh

    Contact information of lead PI


    United Kingdom

    Title of project or programme

    Metabolic and vascular contributors to dementia'

    Source of funding information

    Alzheimer's Society

    Total sum awarded (Euro)

    € 469,107

    Start date of award


    Total duration of award in years



    Research Abstract

    There is compelling evidence to suggest that Alzheimer’s disease (AD) is fundamentally a metabolic disease
    resulting from progressive deficits in cerebral energy metabolism, triggered by vascular pathologies. It is vital that
    the underlying mechanisms are determined to identify targets amenable to intervention. To address this requires
    development and training of the next generation of dementia researchers with the skills to tackle this growing
    problem. Our universities have pledged their support and committed additional funding to enable the training of 8
    PhD students. We propose to encompass the students within a co-ordinated and planned training programme
    supported by an existing network of research groups with specific expertise in metabolic and vascular disease
    from molecule to Man. State-of-the-art and new technologies will be employed that span from cellular and brain
    energetics, metabolomics (including proteomics and lipidomics), novel biophotonic technology for manipulation
    and imaging the brain from the cellular level of the neurovascular unit (confocal and light sheet imaging) to whole
    brain (MR/DTI), measurements of rodent cognition and from cellular to transgenic animals through to human
    studies. The overall outcome will be to provide new insights as to how vascular and metabolic factors lead to
    dysfunction of neuronal networks and progressive cognitive decline.

    Further information available at:

Types: Investments < €500k
Member States: United Kingdom
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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