Name of Resource

    Microglia Cell Model (VU University Medical Center)

    Name of Principal Investigator - Title

    Dr

    Name of Principal Investigator - First name

    Robert

    Name of Principal Investigator - Last name

    Veerhuis

    Address of institution -Institution

    VU university medical center

    Address of institution - Street address

    De Boelelaan 1117

    Address of institution - City

    Amsterdam

    Address of institution - Postcode

    1081HV

    Country

    The Netherlands

    Website
    Contact email
    Summary

    Microglia, isolated from post mortem human brain (obtained from the Netherlands Brain Bank) , are used to compare effects of Alzheimer's, Parkinson's disease and fronto-temporal dementia specific misfolded proteins on inflammasome activation, and to study mechanisms of activation and effects of potential therapeutics. Although culturing protocols are estabished, supply of tissue is a limiting factor, as are the relative low yield in cells and the fact that microglial cells have to be used within 10 days after isolation, and are vulnerable (transport/ cannot be stored frozen).

    Q1a. Please indicate below if your cohort includes or expects to include, incidence of the following conditions? (1)

    Alzheimer's disease & other dementias| Parkinson's disease & PD-related disorders| Prion disease

    Q1b. Does your resource hold

    Microglia, isolated from post mortem human brain

    Q2a. Does the resource act as a centre for access and distribution to external groups (who are not the Principal Investigators (PI) for the resource)?

    Yes

    Q2b. If Yes, what procedures and rules apply for access?

    Access through collaboration with PI only

    Q3a. Does your resource develop experimental models (animal/cell) for external groups?

    No

    Q3b. If YES and your resource is related to an ANIMAL model, what types of models are provided?

    Q3c. If YES and your resource is related to a CELL model, what types of models are provided?

    Patient derived

    Q4a. Is this activity supported as:

    A collaboration

    Q4b. Do you deposit what you supply in any kind of central repository?

    No

    Disease

    Species

    Available to external user

    Full phenotypic character

    Please indicate the phenotypes

    List of genotypes or other subtypes

    Q5b. Cognitive function, No of models

    Q5b. Cognitive function, Available to external users

    Q5b. Cognitive function, Full phenotypic characterisation

    Q5b. Cognitive function, Nature of phenotype

    Q5b. Motor function, No of models

    Q5b. Motor function, Available to external users

    Q5b. Motor function, Full phenotypic characterisation

    Q5b. Motor function, Nature of phenotype

    Q5b. Physiological function, no of models

    Q5b. Physiological function, Available to external users

    Q5b. Physiological function, Full phenotypic characterisation

    Q5b. Physiological function, Nature of phenotype

    Q5b. Other function (please specify), no of models

    Please specify other function

    Q5b. Other function (please specify), Available to external users

    Q5b. Other function (please specify), Full phenotypic characterisation

    Q5b. Other function (please specify), Nature of phenotype

    Q6. Please indicate if your resource is already linked into European or international consortia or networks?

    JPND "InCure" project.

    Q7a. Is maintenance of this resource dependent on continued funding?

    Yes

    Q7b. If yes, when does the current funding period end?

    2018

    Q7c. What is the expected lifespan of the resource (in years)?

    NA; (resource is infrastructure)

    Q7d. Are there other plans affecting future use that it may be useful to know?

    No

Types: Experimental Models
Member States: Netherlands
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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