Principal Investigators

    Jia-Yi Li


    Lund University

    Contact information of lead PI



    Title of project or programme

    Molecular mechanisms of Parkinson pathology spread and potential therapeutic interventions

    Source of funding information

    Swedish Research Council

    Total sum awarded (Euro)

    € 652,884

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Parkinson's disease & PD-related disorders


    Research Abstract

    Dopaminergic neuronal death and alpha-synuclein (a-syn) aggregate formation (Lewy pathology) are the neuropathological hallmarks in Parkinson?s disease (PD). Recent our and other studies have shown that Lewy pathology can be spread from peripheral tissues (e.g. intestine) to the brain, and from one brain region to another. The objective of this project is to explore molecular mechanisms of aggregated a-syn propagation in PD in order to seek for novel therapies to delay the onset and slow down the disease progression. Specifically, we will use multidisciplinary technologies, including live-cell imaging, in vivo two-photon imaging, cell and transgenic mouse models, Drosophila models, AAV viral delivery and stem cell differentiation, to study interaction between genetic susceptibility and environmental risk factors on a-syn aggregation; to determine molecular machinery that control a-syn aggregate transport, to investigate how trans-synaptic transfer of a-syn takes place, to determine the role of autophagy-lysosomal system and UPS, on a-syn propagation, to study their subsequent consequences on neuronal function, e.g. neuroinflammation and synaptic aberrations and at last, to examine effects of specific a-syn antibodies on a-syn transfer and aggregation. The fulfillment of the project will further our understanding on PD pathogenesis and will open new avenues for identifying novel drug targets for small molecules that can restore lost neuronal function in PD.

    Lay Summary

    Further information available at:

Types: Investments > €500k
Member States: Sweden
Diseases: Parkinson's disease & PD-related disorders
Years: 2016
Database Categories: N/A
Database Tags: N/A

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