Title of project or programme

Nature of TSE infection and Routes of Transmission

Principal Investigators of project/programme grant
ProfessorJeanMansonUniversity of EdinburghUnited Kingdom
Address of institution of lead PI
InstitutionThe Roslin Institute, University of Edinburgh
Street AddressEaster Bush, Midlothian
CityEdinburgh, Scotland
PostcodeEH25 9RG

United Kingdom

Source of funding information

Biotechnology and Biological Sciences Research Council

Total sum awarded (Euro)


Start date of award


Total duration of award in months


The project/programme is most relevant to
  • Prion disease
Research abstract in English

We aim to study the biochemical and biophysical nature of different strains of agent and their modes of transfer from animal to animal for the development of specific disease control in combination with efficient health and environmental protection measures. The refinement of diagnostic methods and genetic programmes will be used to eradicate novel TSE agents and provide models for risk reduction in other diseases. We will follow the agent in its route into the host and study the cellular, molecular and genetic mechanisms that enhance or prevent efficient transmission. The objectives of this theme are: To define TSE strains. Understand the TSE infectious agent and diagnosing disease. Define routes of transmission between animals. Understand genetic control of susceptibility/resistance. To define the role of PrP gene regulation in TSE disease. Investigate therapeutic intervention.

Lay summary

    Types: Investments > €500k
    Member States: United Kingdom
    Diseases: Prion disease
    Years: 2011
    Database Categories: N/A
    Database Tags: N/A

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