Principal Investigators

    Per Andrén


    Uppsala University

    Contact information of lead PI



    Title of project or programme

    Neurochemical changes associated with Parkinson´s disease and L-Dopainduced dyskinesia

    Source of funding information

    The Swedish Brain Foundation

    Total sum awarded (Euro)

    € 54,407

    Start date of award


    Total duration of award in years



    Research Abstract

    The main objective of the present research is to study functional neurochemical processes in Parkinson
    disease (PD) and specifically L-3,4-dihydroxyphenyl-alanine (L-DOPA)-induced dyskinesia (LID). To address the issues raised in the present project we have access to a comprehensive and truly unique biobank of primate brain tissue (Macaca fascicularis) consisting of seven experimental groups. Furthermore, we are investigating several novel drug therapeutic approaches emerging for PD and LID and their effect on neurotransmitters, neuropeptides and proteins in rodents. The proposed project utilizes state-of-the-art proteomics and mass spectrometry technology approaches for
    the investigation of neurotransmitter, protein, and peptide concentrations and interactions in the basal ganglia and associated structures in dyskinetic and non-dyskinetic subjects. Pathway analysis is performed to convert quantitative data on the expression levels of proteins and peptides into the quantitative signaling status of the cells. Novel mass spectrometry methodology is used to image and
    quantitate neurotransmitters and their precursors directly in brain tissue sections. The present project is a continuation of the last year’s funded application.

    Further information available at:

Types: Investments < €500k
Member States: Sweden
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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