Principal Investigators

    J. Gsponer, O. Riess, J.Pahnke, E.Aronica, P.Pavlidis



    Contact information of lead PI



    Title of project or programme

    NeuroGeM: Identification of genes that modulate the severity of all neurodegenerative diseases

    Source of funding information

    JPND-Cross Disease

    Total sum awarded (Euro)

    € 1,325,000

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Neurodegenerative disease in general


    Research Abstract

    Neurodegenerative diseases, particularly Alzheimer’s disease and Parkinson’s disease, affect millions of people in the western world. Although some familial forms of these diseases have been identified, the large majority of neurodegenerative diseases are of unknown origin.
    In order to develop new therapeutic and diagnostic tools, it is essential to identify the genetic factors that modulate the risk for neurodegenerative diseases in the large majority of the population.
    We will use a systems medicine approach where we will combine our expertise in computational biology, molecular genetics, animal modelling and neuropathology in order to identify alterations in our genes that increase the risk to develop any type of neurodegenerative disease.
    Identifying these factors will provide new means to correlate genetic findings in patients with the clinical presentation of their disease and to facilitate the search for new biomarkers (i.e., measurable indicators of deviations from healthy ageing or disease progression).

    Lay Summary

    Further information available at:

Types: Investments > €500k, JPND Projects
Member States: Canada, Germany, JPND, Netherlands, Norway
Diseases: Neurodegenerative disease in general
Years: 2016
Database Categories: N/A
Database Tags: N/A

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