Principal Investigators


J. Gsponer, O. Riess, J.Pahnke, E.Aronica, P.Pavlidis

Institution


Multiple

Contact information of lead PI


Country


Canada|Germany|Norway|Netherlands

Title of project or programme


NeuroGeM: Identification of genes that modulate the severity of all neurodegenerative diseases

Source of funding information


JPND-Cross Disease

Total sum awarded (Euro)


€ 1,325,000

Start date of award


01/01/2015

Total duration of award in years


3.0

The project/programme is most relevant to:


Neurodegenerative disease in general

Keywords


Research Abstract


Neurodegenerative diseases, particularly Alzheimer’s disease and Parkinson’s disease, affect millions of people in the western world. Although some familial forms of these diseases have been identified, the large majority of neurodegenerative diseases are of unknown origin.
In order to develop new therapeutic and diagnostic tools, it is essential to identify the genetic factors that modulate the risk for neurodegenerative diseases in the large majority of the population.
We will use a systems medicine approach where we will combine our expertise in computational biology, molecular genetics, animal modelling and neuropathology in order to identify alterations in our genes that increase the risk to develop any type of neurodegenerative disease.
Identifying these factors will provide new means to correlate genetic findings in patients with the clinical presentation of their disease and to facilitate the search for new biomarkers (i.e., measurable indicators of deviations from healthy ageing or disease progression).

Lay Summary


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