Principal Investigators

    Adam Walker


    Macquarie University

    Contact information of lead PI



    Title of project or programme

    Neuroinflammation in frontotemporal dementia: The role of microglia in TDP-43-related disease

    Source of funding information

    Alzheimer's Australia Dementia Research Foundation

    Total sum awarded (Euro)

    € 34,196

    Start date of award


    Total duration of award in years



    Research Abstract

    The brains of patients with frontotemporal dementia (FTD) show inflammation in affected regions, where neurodegeneration has occurred. In the brain, immune cells known as microglia are the main cell type that controls this inflammatory response. Microglia provide a protective surveillance function in the brain to allow rapid response to injury or disease but they can also take on toxic properties that drive neuron death. In FTD, it remains unclear whether inflammatory microglia are protective or toxic to neurons. In this study, microglia and inflammatory molecules will be analysed over time in recently-developed genetically-modified mice that develop disease similar to human FTD, and these mice will be treated with an experimental drug to prevent brain inflammation. Findings from this project will therefore determine if pharmacological alteration of the microglial inflammatory response could be used to modify disease development and progression in FTD.

    Further information available at:

Types: Investments < €500k
Member States: Australia
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

Export as PDF