Principal Investigators

    A/Pr Mark Bellingham


    University of Queensland

    Contact information of lead PI



    Title of project or programme

    Neuronal hyperactivity and neurotrophic factors in motor neuron disease

    Source of funding information

    National Health and Medical Research Council

    Total sum awarded (Euro)

    € 469,222

    Start date of award


    Total duration of award in years



    Research Abstract

    Using mice with mutant genes causing amyotrophic lateral sclerosis, we will test whether motor neuron hyper-excitability during early development causes excessive synapse and dendrite formation, ultimately leading to neuronal death. We will also test whether activity-dependent secretion of neurotrophic factors and activation of their receptors plays a role in this disease. This will show whether neuronal hyper-activity and neurotrophic factor signaling plays a causal role in this disease.

    Further information available at:

Types: Investments < €500k
Member States: Australia
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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