Principal Investigators


A/Pr Mark Bellingham

Institution


University of Queensland

Contact information of lead PI


Country


Australia

Title of project or programme


Neuronal hyperactivity and neurotrophic factors in motor neuron disease

Source of funding information


National Health and Medical Research Council

Total sum awarded (Euro)


€ 469,222

Start date of award


01/01/2014

Total duration of award in years


3

Keywords


Research Abstract


Using mice with mutant genes causing amyotrophic lateral sclerosis, we will test whether motor neuron hyper-excitability during early development causes excessive synapse and dendrite formation, ultimately leading to neuronal death. We will also test whether activity-dependent secretion of neurotrophic factors and activation of their receptors plays a role in this disease. This will show whether neuronal hyper-activity and neurotrophic factor signaling plays a causal role in this disease.

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