RNDr. Lenka Maletínská, CSc.
Institute of Organic Chemistry and Biochemistry of the AS CR, v.v.i.
Neuroprotective effects of novel analogs of anorexigenic prolactin-releasing peptide (PrRP) in mouse models of neurodegeneration and obesity
Czech Science Foundation
Alzheimer disease (AD) has been recently linked to disturbed central insulin signaling, leptin resistance, obesity and type 2 diabetes. Insulin, leptin and glucagon-like peptide-1 agonists showing anorexigenic effect were found to prevent pathological phosphorylation of Tau protein and/or formation of Amyloid beta peptide plaques in animal models of AD. The major aim of our proposal is to find out if novel anorexigenic peripherally administered and centrally acting analogs of prolactin-releasing peptide (PrRP) have similar beneficial effect on the mentioned neurodegenerative changes in hippocampi of APP/PS1 and Thy-Tau 22 mice and their common aged wild type controls fed either with high fat or normal diet, as well as metabolic changes. Implication of PrRP analogs on spatial memory will be also assessed. Besides, effects of PrRP analogs on induced neuronal damage in cultured neurons will be studied. We aim to prove that our novel PrRP analogs have potent beneficial effects on neurodegenerative changes and memory.