Principal Investigators

    RNDr. Lenka Maletínská, CSc.


    Institute of Organic Chemistry and Biochemistry of the AS CR, v.v.i.

    Contact information of lead PI


    Czech Republic

    Title of project or programme

    Neuroprotective effects of novel analogs of anorexigenic prolactin-releasing peptide (PrRP) in mouse models of neurodegeneration and obesity

    Source of funding information

    Czech Science Foundation

    Total sum awarded (Euro)

    € 317,888

    Start date of award


    Total duration of award in years



    Research Abstract

    Alzheimer disease (AD) has been recently linked to disturbed central insulin signaling, leptin resistance, obesity and type 2 diabetes. Insulin, leptin and glucagon-like peptide-1 agonists showing anorexigenic effect were found to prevent pathological phosphorylation of Tau protein and/or formation of Amyloid beta peptide plaques in animal models of AD. The major aim of our proposal is to find out if novel anorexigenic peripherally administered and centrally acting analogs of prolactin-releasing peptide (PrRP) have similar beneficial effect on the mentioned neurodegenerative changes in hippocampi of APP/PS1 and Thy-Tau 22 mice and their common aged wild type controls fed either with high fat or normal diet, as well as metabolic changes. Implication of PrRP analogs on spatial memory will be also assessed. Besides, effects of PrRP analogs on induced neuronal damage in cultured neurons will be studied. We aim to prove that our novel PrRP analogs have potent beneficial effects on neurodegenerative changes and memory.

    Further information available at:

Types: Investments < €500k
Member States: Czech Republic
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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