Principal Investigators


RNDr. Lenka Maletínská, CSc.

Institution


Institute of Organic Chemistry and Biochemistry of the AS CR, v.v.i.

Contact information of lead PI


Country


Czech Republic

Title of project or programme


Neuroprotective effects of novel analogs of anorexigenic prolactin-releasing peptide (PrRP) in mouse models of neurodegeneration and obesity

Source of funding information


Czech Science Foundation

Total sum awarded (Euro)


€ 317,888

Start date of award


01/01/2016

Total duration of award in years


3

Keywords


Research Abstract


Alzheimer disease (AD) has been recently linked to disturbed central insulin signaling, leptin resistance, obesity and type 2 diabetes. Insulin, leptin and glucagon-like peptide-1 agonists showing anorexigenic effect were found to prevent pathological phosphorylation of Tau protein and/or formation of Amyloid beta peptide plaques in animal models of AD. The major aim of our proposal is to find out if novel anorexigenic peripherally administered and centrally acting analogs of prolactin-releasing peptide (PrRP) have similar beneficial effect on the mentioned neurodegenerative changes in hippocampi of APP/PS1 and Thy-Tau 22 mice and their common aged wild type controls fed either with high fat or normal diet, as well as metabolic changes. Implication of PrRP analogs on spatial memory will be also assessed. Besides, effects of PrRP analogs on induced neuronal damage in cultured neurons will be studied. We aim to prove that our novel PrRP analogs have potent beneficial effects on neurodegenerative changes and memory.

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