Neuroscience: molecular basis and clinical applications. 1.
| Title | Forname | Surname | Institution | Country |
| Dr | Luigi | Institute of Biomedical Technologies, CNR, Milan | Institute of Biomedical Technologies, CNR, Milan | Italy |
| Dr | Sale | Neuroscience Institute, CNR, Pisa | Italy | |
| Dr | Nicola | Origlia | Neuroscience Institute, CNR, Pisa | Italy |
| Dr | Marta | Di Carlo | Institute of Biomedical Technologies, CNR, Milan | Italy |
| Dr | Nadia | Canu | Insitute of cell Biology and Neurobiology, CNR, Rome | Italy |
| Dr | Francesca Luisa | Conforti | Insitute of Neurological Sciences, Catania | Italy |
| Institution | Enrica Strettoi, Consiglio Nazionale delle Ricerche |
| Street Address | Neuroscience Institute |
| City | Area della Ricerca, Via Giuseppe Moruzzi 1 |
| Postcode | 56124 Pisa |
Italy
Consiglio Nazionale delle Ricerche
10000000
01-01-2009
60
- Neurodegenerative disease in general
mitochondria, environment, amyloid, signal transduction, synapse, microglia, aging, cell biology, biochemistry, pharmacology, imaging, nanoparticles
The Neuroscience Program of the Italian CNR comprises numerous lines of research headed by investigators of 10 different Institutes located all over the Country. Several laboratories carry on studies on Alzheimer’s, Parkinson’s, Huntington’s and prion disease and other disorders of the CNS. The studies are funded by the CNR, the Italian Ministry of Education, the EU and by numerous national and international foundations and charities. Methods of study range from molecular techniques to epidemiological approaches. The PIs listed above are responsible of the projects listed here (in order):
1) Cellular mechanisms of Parkinson disease: age related alterations in cellular organelles and effects on mitochondrial turnover.
2) Neurotrophic factors and Alzheimer disease: effects of environmental manipulations
3) Signalling mechanisms in Alzheimer disease: direct effects of beta-amyloid on synaptic physiology. Influence of microglial activation and ischemia on brain function in AD.
4) Molecular mechanisms of fibrillogenesis of beta amyloid peptide: biphysical and and biomolecular studies
5) Mechanisms underlying the effect of N-terminal 26-230 tau fragment on synaptic dysfunction and neurodegeneration
6) FUS (fused in sarcoma) mutations in sporadic amyotrophic lateral sclerosis: clinical and genetic analysis.
The Neuroscience Program of the Italian CNR comprises numerous lines of research headed by investigators of 10 different Institutes located all over the Country. Several laboratories carry on studies on Alzheimer’s, Parkinson’s, Huntington’s. ALS and prion disease and other disorders of the CNS. Methods of study range from molecular techniques to epidemiological approaches.