Principal Investigators

    C Zurzolo, R.Melki, M.Jucker, P.Brundin & S.Linse



    Contact information of lead PI



    Title of project or programme

    NeuTARGETs: Targeting the propagation of pathogenic protein assemblies in neurodegenerative disease

    Source of funding information

    JPND-Cross Disease

    Total sum awarded (Euro)

    € 1,369,544

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias|Parkinson's disease & PD-related disorders


    Research Abstract

    Similar to prion diseases, more common fatal neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease are linked to the aggregation of different proteins (including Tau, Abeta and alpha- synuclein in the brain of affected patients. Furthermore most of the resulting brain lesions initially appear in specific brain areas and the pathology progresses along interconnected areas in a predictable manner. Interestingly, it has been shown that similar to the prion protein, these proteins are able to act as seed and to cause the aggregation of the normal protein. Therefore propagation of the aggregates in the brain could be a common mechanism for the propagation of these diseases.
    In this proposal we want to identify the conditions that lead to aggregation of Abeta and a-synuclein, respectively in Alzheimer’s and Parkinson’s and to identify possible targets to perturb the formation and the propagation of the aggregates. We will also analyze the pathway of spreading of these aggregates between neurons in order to identify specific target to stop their diffusion in the brain.

    Lay Summary

    Further information available at:

Types: Investments > €500k, JPND Projects
Member States: France, Germany, JPND, Sweden
Diseases: Alzheimer's disease & other dementias, Parkinson's disease & PD-related disorders
Years: 2016
Database Categories: N/A
Database Tags: N/A

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