Principal Investigators

    Laura Fratiglioni


    Karolinska Institute

    Contact information of lead PI



    Title of project or programme

    New biomarkers in early diagnosis and treatment of AD

    Source of funding information

    Swedish Foundation for Strategic Research

    Total sum awarded (Euro)

    € 3,590,860

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    Research Abstract

    This project has a translational approach starting with in-silico studies followed by the synthesis of new PET tracers for Alzheimer´s disease (AD) tested and validated in well characterized AD cohorts which are characterized based on large data sets of AD subjects from a broad spectrum of cognitive impairment. In silico studies will use state-of-the-art visualization and multi-scale modeling for identification of biomolecular protein structures and property changes and modeling of ligands for amyloid fibrils.amyloid oligomrers and tau ligands .2) Experimental studies will address new plaques and oligomeric tentative PET tracers. 3) In vivo by PET studies using tracers for tau astrocyte and microglia actvation will be performed in patients with mild cognitive impairment (MCI), AD disease and controls and other forms of dementia.The presence of PET amyloid plaque in brain will be investigate in healthy elderly in an epidemiological cohort. Subtypes of AD patients will be defined based upon biomarker pattern by combining different imaging techniques (MRI, PET) with CSF and neuropsychology.The findings will be translated to the prodromal stages of the disease and cognitive normal subjects.With this project design we aim to develop reliable imaging biomarkers that can predict future conversion to AD, discriminate from other dementia disorders as well as target the right population for clinical trials and treatment.

    Lay Summary

    Further information available at:

Types: Investments > €500k
Member States: Sweden
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

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