Principal Investigators


SEN, RANJAN SEN

Institution


National Institute on Aging

Contact information of lead PI


Country


USA

Title of project or programme


NF-kB control of neuronal apoptosis in Alzheimer disease

Source of funding information


NIH (NIA)

Total sum awarded (Euro)


90101.83486

Start date of award


Total duration of award in years


12

Keywords


Acquired Cognitive Impairment... Aging... Alzheimer's Disease... Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)... Brain Disorders... Dementia... Genetics... Immune System... Neurodegenerative... Neurosciences

Research Abstract


During FY16 we accomplished the following: 1. We identified non-coding RNAs (ncRNAs) that are induced in response to inflammatory signaling (IL-1 and TNF) in human neuronal cell lines and an astrocyte cell line, and in primary mouse neurons. 2. We tested different methods to quantitate RelA nuclear translocation to determine the kinetics to nuclear entry and exit of this transcription factor. 3. We evaluated the use of live-cell imaging to determine the kinetics of RelA translocation using a transfected RelA-GFP fusion protein.

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