Principal Investigators

    SEN, RANJAN SEN

    Institution

    National Institute on Aging

    Contact information of lead PI

    Country

    USA

    Title of project or programme

    NF-kB control of neuronal apoptosis in Alzheimer disease

    Source of funding information

    NIH (NIA)

    Total sum awarded (Euro)

    90101.83486

    Start date of award

    Total duration of award in years

    12

    Keywords

    Acquired Cognitive Impairment... Aging... Alzheimer's Disease... Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)... Brain Disorders... Dementia... Genetics... Immune System... Neurodegenerative... Neurosciences

    Research Abstract

    During FY16 we accomplished the following: 1. We identified non-coding RNAs (ncRNAs) that are induced in response to inflammatory signaling (IL-1 and TNF) in human neuronal cell lines and an astrocyte cell line, and in primary mouse neurons. 2. We tested different methods to quantitate RelA nuclear translocation to determine the kinetics to nuclear entry and exit of this transcription factor. 3. We evaluated the use of live-cell imaging to determine the kinetics of RelA translocation using a transfected RelA-GFP fusion protein.

    Further information available at:

Types: Investments < €500k
Member States: United States of America
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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