Professor Ray Chaudhuri
King's College London
United Kingdom
Non-motor symptoms of people with Parkinson's in black African/Caribbean and South Asian population in London: case control study and biomarkers and non-motor subtypes evaluation
Parkinson's UK
45,057
01/02/2015
1
Impact of ethnicity on Parkinson’s symptoms have been poorly investigated although pilot studies from our group and others have suggested important differences in the past between white Caucasians, black African/Caribbean and South Asian population with Parkinson’s. A key difference was different responses to dopaminergic therapy as well as the range of non-motor symptoms (NMS). Similar examples exist for instance in relation to racial differences in hypertension, diabetes mellitus and multiple sclerosis. We feel the proposed project is innovative because:
1. It will be the world first for non-motor profiling and burden assessment of non-white subjects from a well-established local database comparing to a balanced white Caucasians people with Parkinson’s (PwP) population.
2. It will address the economic, social (for instance non-declaration of NMS) and clinical impact of NMS on black African/Caribbean and South Asian population in PwP for the first time.
3. It will endeavour to establish non-motor subtypes of Parkinson’s in non-white PwP as well as natural history and treatment effect (longitudinal study). The work will lay the basis for a larger international study addressing proposed ethnic differences in NMS and a search for biomarkers.