Principal Investigators

    Mgr. Martin Horák, Ph.D.


    Institute of Physiology of the AS CR, v.v.i.

    Contact information of lead PI


    Czech Republic

    Title of project or programme

    Novel hybrid compounds in the cognitive decline caused by neurodegeneration

    Source of funding information

    Czech Science Foundation

    Total sum awarded (Euro)

    € 369,259

    Start date of award


    Total duration of award in years



    Research Abstract

    This project follow-up with ending 5-year project focused on hybrid compounds. Based on preliminary data, we would like to deeply investigate newly designed hybrids combining AChEI pharmacophore and NMDA antagonist pharmacophore in a single molecule. We hypothesize that simultaneous inhibition of AChE and NMDA receptors results in amelioration of the cognitive decline associated with neurodegeneration. Using in vitro pharmacological/toxicological profile screening of newly prepared compounds and deep characterization of NMDA and AChE interaction, one candidate will be selected. Subacute toxicity, bioavailability and dosing scheme for animal model will be assessed. Subsequently, the compound will undergo in vivo behavioral validation of pro-cognitive properties with subsequent ex vivo biochemical assessment of underlying mechanisms of action. Altogether, the pro-cognitive therapeutic value of such hybrid compounds will be determined.

    Further information available at:

Types: Investments < €500k
Member States: Czech Republic
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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