Principal Investigators

    Prof. dr. W.M. van der Flier


    VU Medisch Centrum Amsterdam

    Contact information of lead PI



    Title of project or programme

    Nutrition, the unrecognized determinant in Alzheimer?s disease (NUDAD)

    Source of funding information

    NWO -FCB

    Total sum awarded (Euro)

    € 1,082,002

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    Research Abstract

    Diet likely has an important effect on cognitive health and performance. The most common form of dementia, Alzheimer’s disease (AD), is one of the grand challenges of the 21st century. Prevention of dementia through dietary intervention is an attractive approach, especially since curative therapy is not available now or in the near future. Dietary intervention is relatively safe and cheap, compared to drug development and treatment, but should be based on scientific evidence of the factors involved. NUDAD’s main objective is to identify modifiable dietary risk factors for AD, the preceding stages of mild cognitive impairment (MCI) and preclinical AD (i.e. cognitively normal) in a longitudinal cohort study. We will assemble a prospective cohort of patients at risk of AD (cognitively normal, MCI) and mild AD, with clinical follow-up during three years. In these patients, we will measure food behaviour including taste, smell, hunger /satiety and food preference as determinants of food intake, track food intake using detailed questionnaires, measure energy needs and body composition, and assess nutritional biomarkers in patients’ blood and CSF. These findings will be used to identify risk factors for AD, formulate dietary guidelines for patients with (predementia) AD and to develop recommendations for trial design in stratified patient groups. Ultimately, this will aid in the future development of targeted nutritional products for patients (at risk of) cognitive decline and AD.

    Lay Summary

    Further information available at:

Types: Investments > €500k
Member States: Netherlands
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

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