Principal Investigators

    M. de Carvalho, M.Kuzma-Kozakiewicz, M.Piotrkiewicz, J. Grosskreutz, P.Andersen, S.Petri



    Contact information of lead PI



    Title of project or programme

    ONWebDUALS: ONTology-based Web Database for Understanding Amyotrophic Lateral Sclerosis

    Source of funding information

    JPND-Preventive Strategy Pilot

    Total sum awarded (Euro)

    € 1,250,386

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Motor neurone diseases


    Research Abstract

    Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressive neurodegenerative disease which is characterized by limb weakness, speaking and swallowing impairment and respiratory insufficiency, generally leading to death after 2-3 years of disease progression. Although advances in understanding ALS have been achieved in recent years, there is incomplete information on the potential association between risk factors, genetic mutations, clinical features and survival. For example the role of risk factors is likely to be different for different mutations. To investigate this important interplay we aim to build a standardized database, which should be implemented in the form of a computer system, in order to permit the use of advanced methods of analysis able to recognize relevant associations. This European ALS web-database is intended to include a very large population of patients, derived from the consortium participants and from other European centers by external collaboration, and through interaction with patients’ organizations. With the derived information, it will be possible to suggest specific preventive strategies, to customize precise research studies and to tailor therapeutic trials to particular populations to develop individualized treatment strategies. The expected major implication is a decrease in the social impact of this disorder in Europe

    Lay Summary

    Further information available at:

Types: Investments > €500k, JPND Projects
Member States: Germany, JPND, Poland, Portugal, Sweden
Diseases: Motor neurone diseases
Years: 2016
Database Categories: N/A
Database Tags: N/A

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