Title of cohort


PAQUID

Acronym for cohort


PAQUID

Name of Principal Investigator - Title


Prof

Name of Principal Investigator - First name


Jean-François

Name of Principal Investigator - Last name


DARTIGUES

Address of institution -Institution


ISPED / INSERM U1219 / Université de Bordeaux

Address of institution - Street address


146 rue Léo Saignat

Address of institution - City


BORDEAUX

Address of institution - Postcode


33076

Country


France

Website


Contact email


[email protected]

Funding source


IPSEN France, Novartis Pharma France, CNSA (Caisse Nationale de Solidarité et d’Autonomie), Roche

Q1a. Please indicate below if your cohort includes or expects to include, incidence of the following conditions?


Alzheimer's disease and other dementias| Parkinson's disease

Q1b. When are studies on the above condition(s) expected to become possible?


Already possible

Q2a. In a single sentence what is the stated aim of the cohort?


To study cerebral and functional ageing

Q2b. What distinguishes this cohort from other population cohorts?


Population-based cohort

Q3a. i) Number of publications that involve use of your cohort to date


150

Q3a.ii) Please give up to three examples of studies to date (Principal Investigator, Institution, Title of Study)


Q3b. If data on research outputs are already available please paste the publication list/other data or provide a link to where these data are publicly available


https://www.ncbi.nlm.nih.gov/pubmed/?term=PAQUID

Q3c. If no research has been done as yet, please explain in a few sentences what information (i.e. research findings) you expect will be gained from the population


Q4a. Study criteria: what is the age range of participants at recruitment? Age in years From:


65

Q4a. Study criteria: what is the age range of participants at recruitment? To:


until death

Q4b. Study criteria: what are the inclusion criteria?


65 or more years old subjects, living at home and randomly selected from the electoral rolls in 75 different sites of two French administrative districts

Q4c. Study criteria: what are the exclusion criteria?


Living in an institution

Q5. What is the size of the cohort (i.e. how many participants have enrolled)?


1,000-5,000 participants

Q6a. Please describe what measures are used to characterise participants


Sociodemographic characteristics, lifestyle, medical antecedents, medications, depressive symptomatology and activity limitations were assessed at baseline and each follow-up time. A complete cognitive evaluation with systematic screening for dementia was performed at baseline and each follow-up time.

Q6b. Are there additional measures for participants with a clinical disorder?


Examination by a neurologist or a geriatrician

Q6c. Are there defined primary and secondary endpoints (e.g. defined health parameters)?


Yes

If yes please specify


Primary endpoint: dementia; secondary endpoint: functional evaluation

Q7. What is the study design (select all that apply)?


Prospective cohort| Longitudinal

Q8. Are your cases matched by


Q9a. Does your study include a specialised subset of control participants?


Yes

Q9b. If your study includes a specialised subset of control participants please describe


Participants free of the disease can be used as controls

Q10a. i) Please enter the data collection start date


01/01/1988

Q10a. ii) Please enter the data collection end date


Last follow-up: 2016; however a next follow-up is planned

Q10a. iii) Is data collection for this study


Data collection ongoing| Data analysis ongoing| Closed to new patients

Q10b. If data collection is ongoing, are there plans to continue the cohort study beyond the current projected end date?


Yes - intend to apply for funding

Q11. Is data collected


Only through the study

Other please specify here


Mainly through the study + link with cancer registry

Q12. Is there a system in place to enable re-contact with patients to ask about participation in future studies?


Yes (participants given permission to be re-contacted via PIs)

Q13a. Please give information on the format and availability of data stored in a database (1)


Data summarised in database

% available


100

Q13a. Please give information on the format and availability of data stored in a database (2)


No

% available


Q13a. Please give information on the format and availability of data stored in a database (3)


No

% available


Q13a. Please give information on the format and availability of data stored in a database (4)


No

% available


Other (please specify)


% available


Q13b. Please give information on the format and availability of data held as individual records (1)


Data is held as individual records

% available


100

Q13b. Please give information on the format and availability of data held as individual records (2)


No

% available


Q13b. Please give information on the format and availability of data held as individual records (3)


Data held on computer based records

% available


100

Q13b. Please give information on the format and availability of data held as individual records (4)


No

% available


Please specify language used


French

Q14a. Is data available to other groups?


Yes

Q14b. If data is available to other groups what is the access policy/mechanisms for access?


Apply to PI or co-ordinator at resource| Access independent of collaboration with PI

Q15. What data sharing policy is specified as a condition of use?


No policy exists

Q16a. Are tissues/samples/DNA available to other groups?


No

Q16b i) If yes, please describe below:


Q16b. ii) In what form are tissues/samples/DNA supplied?


Q16b. iii) Is the access policy/mechanism for obtaining samples the same as that for obtaining data (Q14 above)?


Q17. Is information on biological characteristics available to other groups?


No

Number of Patients


% of total cohort

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