Principal Investigators

    A/Pr Daniel Hatters


    University of Melbourne

    Contact information of lead PI



    Title of project or programme

    Pathogenic and adaptive molecular interactions with mutant huntingtin exon 1

    Source of funding information

    National Health and Medical Research Council

    Total sum awarded (Euro)

    € 493,988

    Start date of award


    Total duration of award in years



    Research Abstract

    This project aims to determine how the gene mutation that causes Huntington’s disease (HD) damages cells in the brain. The diseased gene creates a protein that is abnormally sticky, which causes it to form clumps. Our goal is to determine the components of the cell that are disrupted and damaged as clumping happens. Understanding this link will enable therapeutics to be logically designed in efforts to prevent harm to the brain, potentially before symptoms are evident.

    Further information available at:

Types: Investments < €500k
Member States: Australia
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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