Principal Investigators

    Westaway, David


    University of Alberta

    Contact information of lead PI



    Title of project or programme

    Prion Protein Proteostasis

    Source of funding information


    Total sum awarded (Euro)

    € 461,647

    Start date of award


    Total duration of award in years



    Research Abstract

    The prion protein called PrP is needed first as fuel to make misfolded proteins that cause disease and second in a role where the misfolded protein kills brain cells. Surprisingly we have now found that brain cells are “fighting back” in prion infections by reducing the amount of prion protein they make. We call this process down-regulation. We intend to understand how down-regulation works and to find ways to augment this natural process.

    Further information available at:

Types: Investments < €500k
Member States: Canada
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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