Name of Fellow

    Jörg Hanrieder



    Contact information of fellow



    Title of project/programme

    Probing Amyloid Plaque Pathology in Alzheimer´s Disease using Advanced Imaging Mass Spectrometry

    Source of funding information

    Total sum awarded (Euro)

    € 822,677

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    Alzheimer´s disease | Imaging Mass Spectrometry | Plaques | beta-amyloid | Lipids

    Research Abstract

    The major pathological hallmarks of Alzheime´s disease (AD) is the progressive accumulation and aggregation of beta-amyloid (Abeta) and hyperphosphorylated-tau, into neurotoxic deposits. Abeta aggregation has been suggested as a possibly critical, early inducer driving the disease progression. However, the exact molecular processes underlying Abeta plaque pathology remain unknown, which hampers the development of effective AD treatment strategies. The primary goal of this project is therefore to employ advanced molecular imaging mass spectrometry (IMS) to probe the chemical and structural aspects of Abeta plaque pathology in Alzheimer´s disease. In detail, the aim is elucidate chemical properties of diffuse and mature Abeta plaques and their molecular environment in human brain tissue and transgenic mice. A further aim is to establish mechanistic insight in subcellular Abeta aggregation dynamics in transgenic AD mice using metabolic labeling and ultrahigh resolution imaging MS for elucidating spatial and temporal changes in plaque chemistry. In summary, the proposed work will help to establish the chain of molecular events that underlie amyloidogenic protein aggregation in AD pathology with a particular focus on Abeta peptide truncations and plaque- associated neuronal lipids. This will reveal potential therapeutic targets for pharmaceutical treatment of Alzheimer´s disease as well as biomarkers and theragnostic markers to monitor treatment effects.

Types: Fellowships
Member States: Sweden
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

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