Principal Investigators

    Tara Hessa


    Stockholm University

    Contact information of lead PI



    Title of project or programme

    Protein quality control and Disease

    Source of funding information

    Swedish Foundation for Strategic Research

    Total sum awarded (Euro)

    € 652,884

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Parkinson's disease & PD-related disorders


    Research Abstract

    Cells are highly compartmentalized into numerous membrane-bound organelles such as the Endoplasmic reticulum and mitochondria. The membranes that define each organelle contain unique sets of embedded proteins that impart distinct functionalities to that organelle A major goal of this proposal is to understand how this compartmentalization is achieved with high fidelity, and how it is regulated to suit constantly changing cellular demands. Mislocalization of proteins is a constant problem faced by the cell. When mislocalization of certain proteins becomes excessive, it can lead to various diseases including neurodegeneration. Thus, the quality control pathways that selectively recognize and degrade these proteins are crucial to maintaining cellular homeostasis and avoiding disease. The studies proposed in this application aims at understanding the protein quality control and degradation. In the first part, I will explore the role of the of the cytosolic quality control machinery in elimination of mislocalized ER secretory and membrane proteins. In the second part I will study mitochondrial quality control and the role of ER-Mitochondria contacts in Parkinson’s disease. I will employ a range of techniques, including biochemical dissection of in vitro reconstituted pathways and molecular genetic studies in cultured cells. We anticipate that our mechanistic studies will shed light on both a fundamental cell biological problem and the molecular basis of various diseases.

    Lay Summary

    Further information available at:

Types: Investments > €500k
Member States: Sweden
Diseases: Parkinson's disease & PD-related disorders
Years: 2016
Database Categories: N/A
Database Tags: N/A

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