Principal Investigators


Heuser

Institution


Charité - Universitätsmedizin Berlin

Contact information of lead PI


Country


Germany

Title of project or programme


Randomized, controlled study on the use of simvastatin in mild cognitive disorders

Source of funding information


Federal Ministry of Education and Research (BMBF)

Total sum awarded (Euro)


€ 3,996,098

Start date of award


01/11/2008

Total duration of award in years


10.3

The project/programme is most relevant to:


Alzheimer's disease & other dementias

Keywords


Research Abstract


Purpose: Probands with MCI are at high risk to develop Alzheimer´s dementia (AD). Simvastatin may lower the production of Amyloid, a hallmark of AD in the brain. The primary hypothesis of the study is that 60 mg Simvastatin significantly reduces the Clinical Dementia Rating -Sum of boxes (CDR-SOB) in individuals with MCI as compared to MCI receiving placebo or 20 mg Simvastatin

Lay Summary


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