Name of Fellow

    Dr Tony Southall



    Wellcome Trust

    Contact information of fellow


    United Kingdom

    Title of project/programme

    Reprogramming neurons for nervous system repair.

    Source of funding information

    Wellcome Trust

    Total sum awarded (Euro)

    € 1,487,111

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Neurodegenerative disease in general



    Research Abstract

    A long term goal of regenerative medicine and stem cell research is to possess the knowledge to convert cells from one type to another, for repairing of damaged or diseased tissues. Exciting progress has been made in recent years, with the discovery that expression of specific transcription factors (proteins that regulate gene expression) can reprogram differentiated cells back into stem cells or into an alternative differentiated state. To use these methods for curing neurodegenerative diseases and repairing damaged nerves, much more needs to be learnt about how transcription factors normally control genes to specify neuronal cell fate. Neurotransmitters are a key property of neurons, allowing neurons to communicate with each other. This research project involves investigating how neurotransmitter properties of neurons are specified at the gene regulatory level. Cutting edge technology will be used to identify the repertoire of transcription factors expressed in cells with specific neurotransmitter properties. The role of candidate transcription factors in neurotransmitter specification will be investigated, as well as their potential to reprogram the properties of neurons in a living organism. A future aim is to perform parallel experiments in vertebrate systems, bringing the prospect of focused nervous system regeneration, that one step closer.

Types: Fellowships
Member States: United Kingdom
Diseases: Neurodegenerative disease in general
Years: 2016
Database Categories: N/A
Database Tags: N/A

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