Principal Investigators


Prof Robert Richards

Institution


University of Adelaide

Contact information of lead PI


Country


Australia

Title of project or programme


RNA-based Expanded Repeat Pathogenic Pathway in Neurodegenerative Diseases

Source of funding information


National Health and Medical Research Council

Total sum awarded (Euro)


€ 398,753

Start date of award


01/01/2014

Total duration of award in years


4

Keywords


Research Abstract


Many important human genetic diseases (incl Huntington’s Disease) are due to a common mutation mechanism with some similarities in clinical outcome (late in life nerve cell loss). For these diseases it is still not known what mechanism is responsible for causing the disease. This is essential in order to delay onset, slow progression or effect cure. We will test a mechanism for disease pathology that we have identified in a simple model organism and seen evidence of its activity in human disease

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