Principal Investigators

    Schipper, Hyman M


    Jewish General Hospital (Montreal)

    Contact information of lead PI



    Title of project or programme

    Role of HO-1 in Aging & Parkinsonian Neural Tissues III

    Source of funding information


    Total sum awarded (Euro)

    € 490,048

    Start date of award


    Total duration of award in years



    Research Abstract

    Parkinson disease (PD) is the second most common neurodegenerative disorder in the developed world. Although several drugs are available to alleviate some of the symptoms of PD (such as tremor or stiffness), we sorely lack medications which slow the destruction of nerve cells in the affected brain regions. Two abnormalities observed in the PD brain which are thought to contribute to nerve cell damage in this disease are 1) the excessive accumulation of iron and 2) injury to mitochondria, the cells’ power generators. Our laboratory has collected evidence that both of these abnormalities may be caused by an enzyme called heme oxygenase-1 (HO-1) which is overactive in the brains of PD patients. We recently created a mouse model that mimics the increased brain HO-1 seen in individuals with PD. In the current proposal, we will document the deleterious effects of this excessive HO-1 on the structure and chemistry of the brain and the behaviour of the animals. We will then try to cure these mice and other experimental models of PD with medications that purge the brain of excess iron and a new drug we are developing that blocks the action of HO-1. If successful, this study may herald a novel and rational approach to the prevention of brain cell loss in PD and provide fresh hope to sufferers of this debilitating condition.

    Further information available at:

Types: Investments < €500k
Member States: Canada
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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