Principal Investigators

    Professor James Uney


    University of Bristol

    Contact information of lead PI


    United Kingdom

    Title of project or programme

    Screening a neuroactive drug library to identify new treatments for Parkinson's

    Source of funding information

    Parkinson's UK

    Total sum awarded (Euro)

    € 46,985

    Start date of award


    Total duration of award in years



    Research Abstract

    he drug company, Takeda has compiled an in-house multi-drug class library of 1000 novel compounds that cross the blood-brain-barrier. These unique drugs cannot be obtained elsewhere and are available to us through an existing collaboration with Takeda. Significantly, we will use this library in a high-throughput screen of mitochondrial function to identify drugs that are neuroprotective.
    Promising therapeutic compounds will then be tested further using a dopaminergic neuron model of mitochondrial dysfunction and Parkinson’s disease.
    This work is hence innovative, as it will screen a unique library to identify a drug and/or a class of drugs that that could ultimately be developed to protect against the loss of dopaminergic neurons associated with PD.

    Further information available at:

Types: Investments < €500k
Member States: United Kingdom
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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