Principal Investigators




    Contact information of lead PI



    Title of project or programme

    Self-Regulation, Immunological Aging, and Health in Older Adults

    Source of funding information

    NIH (NIA)

    Total sum awarded (Euro)

    € 2,199,979.82

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    Acquired Cognitive Impairment... Aging... Alzheimer's Disease... Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)... Basic Behavioral and Social Science... Behavioral and Social Science... Brain Disorders... Clinical Research... Clinical Research - Extramural... Dementia... Mental Health... Neurodegenerative... Neurosciences... Physical Activity

    Research Abstract

    ? DESCRIPTION (provided by applicant): The parent grant for which this competing revision is being requested (AG026307-R01) evaluates longitudinal relationships between measures of self-regulation and self-control and measures of physical health in older adults, including peripheral markers of cardiovascular and immunological health. Critically, however, older adults high in self-regulation (e.g., conscientiousness) also demonstrate positive health outcomes that implicate improved central nervous system/brain health, such as reduced risk for Alzheimer’s disease, slower cognitive decline, and increased longevity. Despite this apparent link to successful brain aging, relationships between individual differences in trait self-regulation and brain structure and function have not been studied to date. The parent study longitudinally and repeatedly assesses self-regulation and health in older adults (current N=135). Here we seek to broaden this well-established study with multi-modal magnetic resonance imaging (MRI) measures of brain structure and function. The proposed project stands to bridge the knowledge gap between personality and behavioral variants associated with superior health outcomes in older adults and the determinants of successful brain aging. The proposed project will: 1) Examine whether better self-regulation correlates with less evidence of brain structural decline. We and others have shown that healthy behaviors, such as exercise, promote the integrity of white matter tracts and protect against atrophy in the brain. Here volumetric and diffusion tensor imaging will be used to assess relationships between brain structure, self-regulation, and potential behavioral mediators (including physical activity and other healthy behaviors). 2) Examine whether better self-regulation is associated with more youthful brain function. A more youthful pattern of brain activation in older age is one important marker of successful cognitive aging. In our previous work, we have shown that high performing older adults exhibit more youthful patterns and levels of functional activation during cognitive control tasks. Moreover, we have shown that older adults protected by advantageous cognitive traits (e.g., lifelong bilingualism), as a group, exhibit more youthful activation and superior cognitive control task performance compared to age-matched peers. 3) Examine whether better self-regulation correlates with successful compensatory patterns of brain activity. Successful cognitive task performance in older adults is often accompanied by reorganized patterns of brain activation and functional connectivity. Such changes are thought to reflect the functional plasticity of the aging brain and likely reflect a shift in the cognitive strategies used to perform cognitive tasks. Since not all older adults express such compensatory changes, it is important to understand the role that psychological resources, e.g., self-regulation, play in promoting successful adaptation to brain aging.

    Lay Summary

    PUBLIC HEALTH RELEVANCE: People who are high in self-control enjoy a number of health benefits, including reduced risk of neurological disease such as Alzheimer’s disease, but the underlying effects of self-control on brain structure and function are unknown. This project will expand on an existing longitudinal study measuring self-control and health in older adults by adding measures of brain health. We expect that older adults who are typically more self-controlled will show less evidence of age-related decline in brain structure and function.

    Further information available at:

Types: Investments > €500k
Member States: United States of America
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

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