Principal Investigators

    Gilad Silberberg


    Karolinska Institute

    Contact information of lead PI



    Title of project or programme

    Sensory Processing in the Parkinsonian Striatal Microcircuit.

    Source of funding information

    The Swedish Brain Foundation

    Total sum awarded (Euro)

    € 108,814

    Start date of award


    Total duration of award in years



    Research Abstract

    Parkinson’s disease (PD) is primarily characterized as a movement disorder, resulting from the loss of dopaminergic input to striatum, the main input structure of the basal ganglia. PD patients and model animals often exhibit sensory impairments alongside with motor symptoms yet little is
    known about the network alterations underlying these impairments.
    In this project we aim to elucidate the mechanisms underlying sensory deficits in PD. We use a PD animal model, the 6OHDA dopamine-depleted mouse, to study alterations in sensory
    integration performed by striatal neurons. We employ a combination of electrophysiological, optogenetic, and morphological methods to study how the striatal microcircuitry underlying sensory processing is altered following dopamine depletion. Neuronal classification is performed by
    a novel method for electro-optical detection of striatal neurons while whole-cell recording their activity and sensory responses in vivo. Our preliminary results show cell-type dependent changes in sensory integration, affecting striatal projection neurons of the D1 type. This project will increase
    our understanding of Parkinson’s disease, in particular with respect to the relatively unexplored aspect of sensory deficits, and may help develop new ways for early diagnosis of PD.

    Further information available at:

Types: Investments < €500k
Member States: Sweden
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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