Principal Investigators




    Contact information of lead PI



    Title of project or programme

    Software Platform for Analyzing Alzheimers and Parkinsons fMRI Connectomes

    Source of funding information

    NIH (NIA)

    Total sum awarded (Euro)

    € 1,012,790.83

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    Acquired Cognitive Impairment... Aging... Alzheimer's Disease... Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)... Bioengineering... Biomedical Informatics Research... Biomedical Information Resources... Biomedical Information Resources and Informatics Research... Brain Disorders... Dementia... Diagnostic Radiology... Networking and Information Technology R&D... Neurodegenerative... Neurosciences... Parkinson's Disease... Translational Research

    Research Abstract

    ? DESCRIPTION (provided by applicant): It is estimated that the cost in the US for brain disorders per year is $500 billion for treatment and long term care, with another $400 billion in other nonmedical costs. As a consequence, reducing the burden of human brain disorders is a key focus of the NIH BRAIN Initiative, with one strategy being the use of fMRI connectomes to study brain region functioning. Current approaches for analyzing connectomes use ‘off-the-shelf’ statistical methods not optimized for this type of data. In this Direct to Phase II SBIR we propose to further develop and strengthen our graphical object oriented data analysis software to solve data analysis, experimental design, and hypothesis testing problems in translational neuroscience. Product: This SBIR will produce analytical software for fMRI data in translational research. Users will access the software through a cloud-based Software-as-a-Service (SaaS) contract. The technical innovation of this SBIR statistical software designed specifically and optimized for fMRI brain imaging data is to support moving fMRI technology from basic R&D to translational clinical science. The impact of this technology are tools to improve brain imaging experimental design, improve biostatistical analysis of brain imaging data, and ultimately improve discovery of biomarkers and identify possible drug targets for clinical treatment. Long term goal: Extending our cloud-based Software-as-a-Service (SaaS) data analytics platform offers researchers an easy to use web-based interface for analyzing new and complex biomedical research data. As a platform technology, there are many applications in other areas of biomedical research that can be developed. Therefore, our business strategy is to identify the areas of science that have the greatest potential to make the move from the university research setting into the commercial arena, and that produce novel or complex data with no commercial analytics tools for translational clinical trials yet on the market. The Specific Aims of this SBIR Direct to Phase II project are: Aim 1: Develop statistical algorithms and software. Aim 2: Validate the methods. Aim 3: Apply the methods to real data. Expected outcomes: Validated statistical software proven to be more powerful than existing methods for analyzing fMRI connectome data in translational research.

    Lay Summary

    PUBLIC HEALTH RELEVANCE: Brain imaging is seen as a new way to discover ‘biomarkers’ that might be used in the clinic to diagnose diseases like Alzheimer’s or Parkinson’s early, and a new way to help develop drugs for these types of diseases. This project is creating statistical software that will help researchers find and test these biomarkers, and speed up the development of new treatments.

    Further information available at:

Types: Investments > €500k
Member States: United States of America
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

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